DARZALEX® Treatment:

DARZALEX® in combination with Velcade® 
(bortezomib) + melphalan + prednisone

The frequency and length of DARZALEX® infusions decreases over time.

On average, the first DARZALEX® infusion may take about 7 hours. Future infusions will take less time, and last 3 to 5 hours, not including check-in and check-out time. After the initial rounds, DARZALEX® treatments are needed only once every four weeks.

Other medicines in this regimen are given as follows:

  • Velcade (bortezomib) by injection twice a week in weeks 1, 2, 4, and 5 of the first 6-week cycle, then once a week in weeks 1, 2, 4, and 5 of the next eight 6-week cycles
  • melphalan by mouth on days 1 to 4 of the nine 6-week cycles
  • prednisone by mouth on days 1 to 4 of the nine 6-week cycles