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A new option for patients with multiple myeloma: DARZALEX® can now be used in combination with Revlimid® (lenalidomide) and dexamethasone or Velcade® (bortezomib) and dexamethasone in patients who have received at least one prior medicine.

How does DARZALEX® work?
  • DARZALEX® is not chemotherapy. DARZALEX® is a monoclonal antibody that works with your immune system. Monoclonal antibodies work by attaching themselves to multiple myeloma cells in your body and directly killing them, and/or signaling your immune system to destroy them
  • DARZALEX® finds and attaches to a protein called CD38, which is present on the surface of cells, including high numbers on myeloma cells
RESULTS SEEN IN CLINICAL TRIALS
  • The main goal of the study was to measure the length of time patients live without their multiple myeloma getting worse or their passing away from any cause
    • Another goal was to measure response rate, which is the percentage of patients who responded to treatment. Talk to your doctor about how response is measured
  • The majority of patients responded to the following DARZALEX® combination treatments:
    • ​DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
      • 9 out of 10 patients responded to DARZALEX® + Rd vs 7 out of 10 with Rd alone
    • DARZALEX® was studied in combination with Velcade® and dexamethasone (Vd) vs Vd alone in 498 patients who had received a minimum of 1 prior treatment
      • Almost 8 out of 10 patients responded to DARZALEX® + Vd vs almost 6 out of 10 with Vd alone
  • DARZALEX® combination treatments reduced patients’ risk of their disease getting worse or their passing away from any cause by more than 60%

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Revlimid® is a registered trademark of Celgene Corporation.
Velcade® is a registered trademark of Millennium Pharmaceuticals, Inc.

Immune system

Several types of cells and organs that work together to help the body fight infections and other diseases.

Immunomodulatory agents

Drugs that change a patient’s immune response by enhancing or suppressing the immune system.

Inflammation

A condition in which a part of your body becomes red, swollen, and painful, as a result of an irritation, infection, or injury.

Infusion reaction

A side effect seen with some drugs that are given intravenously.

Intravenous (IV) infusion

A way of giving medicines or other fluids by inserting them into the bloodstream through a needle or tube in a vein.

Median

The middle number in an ordered set of values arranged from smallest to largest. Example: 3, 5, 12. The median is 5.

Monoclonal antibody

A man-made molecule that binds to substances in the body, including cancer cells. Monoclonal antibodies work with your immune system.

Proteasome inhibitors (PIs)

Drugs that slow down cancer cell growth by interfering with processes that play a role in cell function.

Protein

Molecule made up of amino acids and needed for the body to function properly. Proteins are the basis of skin, hair, and other substances in the body.

Relapse

The return or worsening of a disease that had previously responded to therapy.

Response

A measure by which an improvement related to treatment is determined by a healthcare professional or clinical trial.