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Side Effects | DARZALEX® IV (daratumumab)

DARZALEX® side effects

Side effects

A side effect is an unwanted or unexpected reaction to a drug. Tell a member of your healthcare team if you have any side effect that bothers you or that does not go away.

The most common side effects of DARZALEX® include cold-like symptoms (upper respiratory infection); diarrhea; constipation; decreased red blood cells; nerve damage causing tingling, numbness, or pain; tiredness; swollen hands, ankles, or feet; nausea; cough; fever; shortness of breath; feeling weak.

Infusion Reactions

Infusion reactions are common with DARZALEX® and can be severe. About half the people treated with DARZALEX® experience an infusion reaction. This is most likely to happen during the first infusion and less likely with future infusions. A healthcare professional will monitor you during every DARZALEX® infusion.

If you do have an infusion reaction, your healthcare professional may temporarily stop your infusion or completely stop treatment with DARZALEX®.

Infusion reaction symptoms may include:

  • shortness of breath or trouble breathing
  • dizziness or lightheadedness (hypotension)
  • cough
  • wheezing
  • heart beating faster than usual
  • low oxygen in the blood (hypoxia)
  • throat tightness or irritation
  • runny or stuffy nose
  • headache
  • itching
  • high blood pressure
  • eye pain
  • nausea
  • vomiting
  • chills
  • fever
  • chest discomfort
  • or blurred vision

Questions to ask before and after treatment

Here are a few things you may want to ask your doctor so you can be better prepared for treatment with DARZALEX®:

  • What side effects should I watch for?
  • Do I need to make any changes to my diet during or after treatment?
  • What kind of exercise can or should I do while being treated?
  • What type of follow-up will I need after treatment and when?
  • How will we know if the cancer has come back? What should I watch for?

Generate your own list of questions with our Personalized Doctor Conversation Starter