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What to Expect | DARZALEX® IV (daratumumab)

What to expect before, during, and after treatment with DARZALEX®

If this is the first time you’re receiving a DARZALEX® infusion, you may have some questions about what it’s like and what you need to do. Hopefully, this will provide some answers.

Be prepared for your infusion

The day before
Make sure you drink plenty of fluids

That morning
Eat a healthy breakfast

Set aside enough time

On average, the first infusion may take about seven hours. Future infusions will take less time and last three to five hours. So make sure you set aside enough time in your day.

First infusion may take about seven hours

Future infusions will last three to five hours

Dress for comfort

 Wear comfortable, loose-fitting, and layered clothing. You’ll want to be comfortable and able to adjust your clothing depending on the temperature in the infusion room.

DARZALEX® patient, on his infusion day wardrobe

“I wear very comfortable clothing. Usually I wear shorts and a T-shirt. You’ll be using the bathroom quite a bit from all the fluids you get, so elastic shorts can help.”

Watch Patients’ Stories

Bring a few things with you

To pass the time
Headphones, a music player, a tablet, crossword puzzles, or a book.

To help you relax
Blanket and pillow to help you get comfortable in case you want to take a nap.

To eat and drink
Snacks and drinks for the day. Check with the facility to see if bringing food is okay.

Before your infusion begins

Your healthcare professional will also do blood tests to match your blood type before you start treatment. This is because DARZALEX® can affect blood test results used to match your blood for transfusions. These changes can last for up to six months after your final dose of DARZALEX®. Tell all your healthcare professionals that you are being treated with DARZALEX® before receiving blood transfusions.

DARZALEX® patient, on his infusion day

“I have my blood work done a day or two before infusion. And I take food or snacks with me. I usually have my infusion done on the weekends. It’s much less crowded in the treatment center.”

Watch Patients’ Stories

During the infusion

 Pay attention to how you feel. Let the healthcare staff know about any discomfort, even if it’s just a cough, runny nose, or throat discomfort, during or after treatment and especially during your first infusion. You could be having a reaction to treatment with DARZALEX®.

Do not receive DARZALEX® if you have a history of a severe allergic reaction to daratumumab or any of the ingredients in DARZALEX®.

Infusion reaction symptoms may include:

  • shortness of breath or trouble breathing
  • dizziness or lightheadedness (hypotension)
  • cough
  • wheezing
  • heart beating faster than usual
  • low oxygen in the blood (hypoxia)
  • throat tightness or irritation
  • runny or stuffy nose
  • headache
  • itching
  • high blood pressure
  • eye pain
  • nausea
  • vomiting
  • chills
  • fever
  • chest discomfort
  • or blurred vision

It is important to tell your doctor or nurse about a reaction as soon as possible so he or she can put an appropriate plan in place.

Infusion reactions are common with DARZALEX® and can be severe. About half the people treated with DARZALEX® experience an infusion reaction. This is most likely to happen during the first infusion and less likely with future infusions.

If you do have an infusion reaction, your healthcare professional may temporarily stop your infusion or completely stop treatment with DARZALEX®.

Go home and rest

It’s not unusual to be tired after the infusion. So it might be a good idea to have a friend drop you off and pick you up—or stay and keep you company. If you have any symptoms of an infusion reaction, get medical help right away.

Janssen CarePath can identify independent organizations which may provide assistance with costs associated with travel to and from treatment.

Contact Janssen CarePath

After the infusion

You will be given medicines, like an oral corticosteroid, to take once you go home to help reduce the risk of a delayed infusion reaction. If you have a history of breathing problems, such as chronic obstructive pulmonary disease (COPD), you may be given additional medicines, such as bronchodilators or inhaled corticosteroids.

Janssen CarePath will help you find the resources you may need to get started and stay on track