Learn about DARZALEX FASPRO® + VRd, the latest FDA-approved quad treatment combination for people with newly diagnosed multiple myeloma who are not eligible to receive a stem cell transplant

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DARZALEX FASPRO ® is now FDA approved as the first therapy for use alone to treat adults with high-risk smoldering multiple myeloma.

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Starting TreatmentHow Treatment Is Given

How DARZALEX FASPRO® and DARZALEX® are given

How DARZALEX FASPRO® is given

DARZALEX FASPRO® is given in about 3 to 5 minutes as an injection under the skin (subcutaneous) in the stomach area (abdomen)

~3 to 5 minutes refers to the time it takes to administer DARZALEX FASPRO® and does not account for all aspects of treatment.

  • The dosing schedule for DARZALEX FASPRO® depends upon the treatment regimen prescribed

Find out which dosing schedule aligns to your treatment regimen.

Find your schedule
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Over time, people receiving DARZALEX FASPRO® may need treatment less often. Daratumumab is the only anti-CD38 monoclonal antibody that can be tapered down to once-monthly dosing after 25 weeks.

  • Does not apply to patients on the DVTd regimen, who receive a fixed number of DARZALEX FASPRO® injections

DVTd=DARZALEX® or DARZALEX FASPRO® (D) + bortezomib (V) + thalidomide (T) + dexamethasone (d).

How DARZALEX® is Given

DARZALEX® is an intravenous (IV) infusion, given through a needle placed in a vein by a healthcare professional. It may be given alone or with other medicines to treat your multiple myeloma.

Average length of infusion

DARZALEX® infusion timeline options

Your healthcare providers will determine your dose of DARZALEX® based on your weight, the time between doses, and which DARZALEX® regimen you are to receive.

If you miss an appointment, be sure to call your doctor as soon as possible to reschedule.

Over time, people receiving DARZALEX® may need treatment less often. Daratumumab is the only anti-CD38 monoclonal antibody that can be tapered down to once-monthly dosing after 25 weeks.

DARZALEX FASPRO® and DARZALEX® dosing and administration schedules

Depending on your regimen, you can get down to once-monthly dosing after

25weeks

Weeks 1 to 6 (6 doses total)DARZALEX FASPRO® is given every week

Weeks 7 to 24 (6 doses total)DARZALEX FASPRO® is given every 3 weeks

Week 25 until disease gets worseDARZALEX FASPRO® is given every 4 weeks

Dosing for DARZALEX FASPRO® when given in combination with VRd
INDUCTION: DARZALEX FASPRO® + VRd
(Given before stem cell transplant)

Weeks 1 to 8 (8 doses total)DARZALEX FASPRO® is given every week

Weeks 9 to 16 (4 doses total)DARZALEX FASPRO® is given every 2 weeks

Stop for high-dose chemotherapy and a stem cell transplant that uses your own stem cells

CONSOLIDATION: DARZALEX FASPRO® + VRd
(Given after stem cell transplant)

Weeks 1 to 8* (4 doses total)DARZALEX FASPRO® is given every 2 weeks

*Treatment restarted at Week 1 after recovery from stem cell transplant.

Weeks 1 to 8 (8 doses total)Every week

Weeks 9 to 24 (8 doses total)Every 2 weeks

After Week 24Every 4 weeks

Approximately 13 doses per year after Week 24

Weeks 1 to 6 (6 doses total)Every week

Weeks 7 to 54 (16 doses total)Every 3 weeks

After Week 54Every 4 weeks

Approximately 13 doses per year after Week 54

INDUCTION: DARZALEX FASPRO® or DARZALEX® + VTd
(Given before stem cell transplant)

Weeks 1 to 8 (8 doses total)Every week

Weeks 9 to 16 (4 doses total)Every 2 weeks

Stop for high-dose chemotherapy and a stem cell transplant that uses your own stem cells

CONSOLIDATION: DARZALEX FASPRO® or DARZALEX® + VTd
(Given after stem cell transplant)

Weeks 1 to 8* (4 doses total)Every 2 weeks

Approximately 16 injections

*Treatment restarted at Week 1 after recovery from stem cell transplant.

Weeks 1 to 8 (8 doses total)Every week

Weeks 9 to 24 (8 doses total)Every 2 weeks

After Week 24Every 4 weeks

Approximately 13 doses per year after Week 24

Weeks 1 to 9 (9 doses total)Every week

Weeks 10 to 24 (5 doses total)Every 3 weeks

After Week 24Every 4 weeks

Approximately 13 doses per year after Week 24

Weeks 1 to 8 (8 doses total)Every week

Weeks 9 to 24 (8 doses total)Every 2 weeks

After Week 24Every 4 weeks

Approximately 20 injections per year until treatment is stopped

Weeks 1 to 8 (8 doses total)Every week

Weeks 9 to 24 (8 doses total)Every 2 weeks

After Week 24Every 4 weeks

Approximately 13 doses per year after Week 24

Your care team will determine the dosing for bortezomib (V), lenalidomide (R), and dexamethasone (d) using each drug’s product information.

Your healthcare provider will develop a treatment plan that is suited to your needs. If you have questions about your regimen, follow up with your doctor.

You can create a list of questions to ask your doctor at your next appointment.

Create the list
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