How Is DARZALEX® Given and How Often?

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NEWS ABOUT DARZALEX®

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A new option for patients with multiple myeloma: DARZALEX® can now be used in combination with Revlimid® (lenalidomide) and dexamethasone or Velcade® (bortezomib) and dexamethasone in patients who have received at least one prior medicine.

How does DARZALEX® work?
  • DARZALEX® is not chemotherapy. DARZALEX® is a monoclonal antibody that works with your immune system. Monoclonal antibodies work by attaching themselves to multiple myeloma cells in your body and directly killing them, and/or signaling your immune system to destroy them
  • DARZALEX® finds and attaches to a protein called CD38, which is present on the surface of cells, including high numbers on myeloma cells
RESULTS SEEN IN CLINICAL TRIALS
  • The main goal of the study was to measure the length of time patients live without their multiple myeloma getting worse or their passing away from any cause
    • Another goal was to measure response rate, which is the percentage of patients who responded to treatment. Talk to your doctor about how response is measured
  • The majority of patients responded to the following DARZALEX® combination treatments:
    • ​DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
      • 9 out of 10 patients responded to DARZALEX® + Rd vs 7 out of 10 with Rd alone
    • DARZALEX® was studied in combination with Velcade® and dexamethasone (Vd) vs Vd alone in 498 patients who had received a minimum of 1 prior treatment
      • Almost 8 out of 10 patients responded to DARZALEX® + Vd vs almost 6 out of 10 with Vd alone
  • DARZALEX® combination treatments reduced patients’ risk of their disease getting worse or their passing away from any cause by more than 60%

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Revlimid® is a registered trademark of Celgene Corporation.
Velcade® is a registered trademark of Millennium Pharmaceuticals, Inc.

How Is DARZALEX® Given?

How Is DARZALEX® Given?

DARZALEX® is administered by a healthcare professional as an intravenous (IV) infusion. Your doctor will work out your dose of DARZALEX® according to your body weight. You will be given DARZALEX® according to the schedule below.

 

Watch a video about what to expect before, during, and after DARZALEX® treatment

To view the full Patient Information, please click here.

 

How Often Is DARZALEX® Given?

DARZALEX® Dosing Schedule

The recommended dose of DARZALEX® is 16 mg/kg of body weight.

Weeks 1–8: Once a week

DARZALEX® (daratumumab) Dosing Schedule

DARZALEX® (daratumumab) Dosing Schedule

 
Weeks 9–24: Once every 2 weeks

DARZALEX® (daratumumab) Dosing Schedule

DARZALEX® (daratumumab) Dosing Schedule

DARZALEX® (daratumumab) Dosing Schedule

DARZALEX® (daratumumab) Dosing Schedule

 
Week 25 onward: Once every 4 weeks

DARZALEX® (daratumumab) Dosing Schedule

DARZALEX® (daratumumab) Dosing Schedule

It is recommended that you continue treatment with DARZALEX® as long as your doctor tells you to.

DARZALEX® Treatment
My Treatment Schedule

Select the date on which you expect to receive your first DARZALEX® treatment. Once a date is selected, recommended subsequent treatment dates will automatically populate within the calendar.*

Tap a date below to begin.
My Treatment Schedule

Select the date on which you expect to receive your first DARZALEX® treatment. Once a date is selected, recommended subsequent treatment dates will automatically populate within the calendar.*

Tap a date below to begin.
Infusion Dates
Weeks 1-8
Weekly Infusions
Weeks 1-8 (weekly infusions)
Weeks 9-24
Infusions Every 2 Weeks
Weeks 9-24 (infusions every 2 weeks)
Weeks 25+
Infusions Every 4 Weeks
Weeks 25+ (infusions every 4 weeks)

* Please note that dates provided are recommendations for infusion visits only. Your doctor is likely to schedule additional follow-up/care visits and may alter the dates for your infusions depending on your availability and office availability.

Infusion centers may not offer weekend and/or holiday appointments.

Please contact the center to confirm hours of operation.

You have chosen a new start date.

Would you like to clear your old dosing schedule and create a new one?

Please select the date you plan to receive your first DARZALEX® dose.

Want a PDF of this treatment schedule?

Learn about some useful tips to help you prepare for your infusions and feel comfortable during your appointments.