Preparing for Treatment




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A new option for patients with multiple myeloma: DARZALEX® can now be used in combination with Revlimid® (lenalidomide) and dexamethasone or Velcade® (bortezomib) and dexamethasone in patients who have received at least one prior medicine.

How does DARZALEX® work?
  • DARZALEX® is not chemotherapy. DARZALEX® is a monoclonal antibody that works with your immune system. Monoclonal antibodies work by attaching themselves to multiple myeloma cells in your body and directly killing them, and/or signaling your immune system to destroy them
  • DARZALEX® finds and attaches to a protein called CD38, which is present on the surface of cells, including high numbers on myeloma cells
  • The main goal of the study was to measure the length of time patients live without their multiple myeloma getting worse or their passing away from any cause
    • Another goal was to measure response rate, which is the percentage of patients who responded to treatment. Talk to your doctor about how response is measured
  • The majority of patients responded to the following DARZALEX® combination treatments:
    • ​DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
      • 9 out of 10 patients responded to DARZALEX® + Rd vs 7 out of 10 with Rd alone
    • DARZALEX® was studied in combination with Velcade® and dexamethasone (Vd) vs Vd alone in 498 patients who had received a minimum of 1 prior treatment
      • Almost 8 out of 10 patients responded to DARZALEX® + Vd vs almost 6 out of 10 with Vd alone
  • DARZALEX® combination treatments reduced patients’ risk of their disease getting worse or their passing away from any cause by more than 60%

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Revlimid® is a registered trademark of Celgene Corporation.
Velcade® is a registered trademark of Millennium Pharmaceuticals, Inc.

What Can I Expect Before DARZALEX® Treatment?

Your healthcare provider will give you medicines before each dose of DARZALEX® to help reduce the risk of infusion reactions. These include:

  • Medicines to prevent an allergic reaction (antihistamines)
  • Medicines to prevent inflammation (corticosteroids)
  • Medicines to reduce fever, such as acetaminophen (antipyretics)

Your healthcare provider will also do blood tests to match your blood type before you start treatment with DARZALEX®. This is because DARZALEX® can affect blood test results used to match your blood for transfusions. These changes can last for up to 6 months after your final dose of DARZALEX®. Tell all of your healthcare providers that you are being treated with DARZALEX® before receiving blood transfusions.


How Is DARZALEX® Given?

Leading Up to Your Infusion

  • Know what to expect:

    On average, the first infusion may take about 7 hours. Future infusions will take less time, but they will still last 3 to 5 hours. So make sure you set aside enough time in your day

  • Wear comfortable, layered clothing:

    Wear comfortable, loose-fitting, and layered clothing. You will want to be comfortable and able to adjust your clothing depending on the temperature in the infusion room

  • Stay hydrated:

    Remember to take in fluids before your infusion. Be sure to avoid alcohol and caffeine. Being hydrated may make it easier for your healthcare provider to access your vein


What to Bring to the Infusion Room

  • Your favorite activities:

    Bring headphones, a music player, a tablet, crossword puzzles, or a book to help you pass the time. Ask the infusion center if they have amenities such as Wi-Fi, a television, or a DVD player

  • Blanket and pillow:

    Bring these and anything else that will help you get comfortable, as you may want to take a nap

  • Drinks and snacks:

    Infusions take hours. Bring something to eat and drink throughout the day. Be sure to check with the facility first that bringing food is OK


Patient and Caregiver Stories

Learn from patients on DARZALEX® and their caregivers about their experiences.

Questions for Your Healthcare Provider

It is important to have conversations with your healthcare provider, and bringing these questions with you to your appointment may help.

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