Patient Stories: Debby’s Story

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NEWS ABOUT DARZALEX®

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A new option for patients with multiple myeloma: DARZALEX® can now be used in combination with Revlimid® (lenalidomide) and dexamethasone or Velcade® (bortezomib) and dexamethasone in patients who have received at least one prior medicine.

How does DARZALEX® work?
  • DARZALEX® is not chemotherapy. DARZALEX® is a monoclonal antibody that works with your immune system. Monoclonal antibodies work by attaching themselves to multiple myeloma cells in your body and directly killing them, and/or signaling your immune system to destroy them
  • DARZALEX® finds and attaches to a protein called CD38, which is present on the surface of cells, including high numbers on myeloma cells
RESULTS SEEN IN CLINICAL TRIALS
  • The main goal of the study was to measure the length of time patients live without their multiple myeloma getting worse or their passing away from any cause
    • Another goal was to measure response rate, which is the percentage of patients who responded to treatment. Talk to your doctor about how response is measured
  • The majority of patients responded to the following DARZALEX® combination treatments:
    • ​DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
      • 9 out of 10 patients responded to DARZALEX® + Rd vs 7 out of 10 with Rd alone
    • DARZALEX® was studied in combination with Velcade® and dexamethasone (Vd) vs Vd alone in 498 patients who had received a minimum of 1 prior treatment
      • Almost 8 out of 10 patients responded to DARZALEX® + Vd vs almost 6 out of 10 with Vd alone
  • DARZALEX® combination treatments reduced patients’ risk of their disease getting worse or their passing away from any cause by more than 60%

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Revlimid® is a registered trademark of Celgene Corporation.
Velcade® is a registered trademark of Millennium Pharmaceuticals, Inc.

Debby | Patient

Living with multiple myeloma since 2009

Patient Debby Living with Multiple Myeloma Story

My husband Harry and I were ready for retirement—we sold our home and a majority of our belongings and were ready to move to a warmer climate and build our dream home. Before leaving, I went to have my yearly physical with my doctor. A few days later, I received a phone call from my doctor, who asked me to come back in for blood work and more diagnostic testing. She also asked me if I was tired, and I said yes, I’m tired—everyone is tired—because you’re running around and doing a thousand things over the course of the day. That’s just a part of life.

A week later I got a bone marrow biopsy, which confirmed that I had multiple myeloma, and I was immediately put on a combination therapy.

My family was shocked, especially my daughter, who requested that I get a second opinion. I was impressed about the vast knowledge this doctor had about multiple myeloma. He restaged my disease and modified my treatment accordingly.

Harry and I moved back to our original town so I could be closer to my doctors. I was scheduled for a stem cell transplant; however, my daughter was getting married that month, and I knew that I wanted to be there, so I held off on the treatment until afterwards. Honestly, I’m very grateful I did, and I was able to be at the wedding. This disease really changes your perspective on what is important.

My multiple myeloma came back, and I started another treatment, which didn’t last long. It was becoming obvious that I was going to be a patient who was resistant to therapy. I am constantly looking for the next product, just in case. I am truly thankful that there is ongoing research for patients like me!

Read Harry’s story about being Debby’s husband and caregiver.

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