Patient Stories: Debby’s Story
- DARZALEX® is not chemotherapy. DARZALEX® is a monoclonal antibody that works with your immune system. Monoclonal antibodies work by attaching themselves to multiple myeloma cells in your body and directly killing them, and/or signaling your immune system to destroy them
- DARZALEX® finds and attaches to a protein called CD38, which is present on the surface of cells, including high numbers on myeloma cells
The main goal of the study was to measure the length of time patients live without their multiple myeloma getting worse or their passing away from any cause
- Another goal was to measure response rate, which is the percentage of patients who responded to treatment. Talk to your doctor about how response is measured
The majority of patients responded to the following DARZALEX® combination treatments:
DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
- 9 out of 10 patients responded to DARZALEX® + Rd vs 7 out of 10 with Rd alone
DARZALEX® was studied in combination with Velcade® and dexamethasone (Vd) vs Vd alone in 498 patients who had received a minimum of 1 prior treatment
- Almost 8 out of 10 patients responded to DARZALEX® + Vd vs almost 6 out of 10 with Vd alone
- DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
- DARZALEX® combination treatments reduced patients’ risk of their disease getting worse or their passing away from any cause by more than 60%
Click here if you are a healthcare professional.
Revlimid® is a registered trademark of Celgene Corporation.
Velcade® is a registered trademark of Millennium Pharmaceuticals, Inc.
Debby | Patient
Living with multiple myeloma since 2009
My husband Harry and I were ready for retirement—we sold our home and a majority of our belongings and were ready to move to a warmer climate and build our dream home. Before leaving, I went to have my yearly physical with my doctor. A few days later, I received a phone call from my doctor, who asked me to come back in for blood work and more diagnostic testing. She also asked me if I was tired, and I said yes, I’m tired—everyone is tired—because you’re running around and doing a thousand things over the course of the day. That’s just a part of life.
A week later I got a bone marrow biopsy, which confirmed that I had multiple myeloma, and I was immediately put on a combination therapy.
My family was shocked, especially my daughter, who requested that I get a second opinion. I was impressed about the vast knowledge this doctor had about multiple myeloma. He restaged my disease and modified my treatment accordingly.
Harry and I moved back to our original town so I could be closer to my doctors. I was scheduled for a stem cell transplant; however, my daughter was getting married that month, and I knew that I wanted to be there, so I held off on the treatment until afterwards. Honestly, I’m very grateful I did, and I was able to be at the wedding. This disease really changes your perspective on what is important.
My multiple myeloma came back, and I started another treatment, which didn’t last long. It was becoming obvious that I was going to be a patient who was resistant to therapy. I am constantly looking for the next product, just in case. I am truly thankful that there is ongoing research for patients like me!
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