Patient Stories: E.C.’s Story
- DARZALEX® is not chemotherapy. DARZALEX® is a monoclonal antibody that works with your immune system. Monoclonal antibodies work by attaching themselves to multiple myeloma cells in your body and directly killing them, and/or signaling your immune system to destroy them
- DARZALEX® finds and attaches to a protein called CD38, which is present on the surface of cells, including high numbers on myeloma cells
The main goal of the study was to measure the length of time patients live without their multiple myeloma getting worse or their passing away from any cause
- Another goal was to measure response rate, which is the percentage of patients who responded to treatment. Talk to your doctor about how response is measured
The majority of patients responded to the following DARZALEX® combination treatments:
DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
- 9 out of 10 patients responded to DARZALEX® + Rd vs 7 out of 10 with Rd alone
DARZALEX® was studied in combination with Velcade® and dexamethasone (Vd) vs Vd alone in 498 patients who had received a minimum of 1 prior treatment
- Almost 8 out of 10 patients responded to DARZALEX® + Vd vs almost 6 out of 10 with Vd alone
- DARZALEX® was studied in combination with Revlimid® and dexamethasone (Rd) vs Rd alone in 569 patients who had received a minimum of 1 prior treatment
- DARZALEX® combination treatments reduced patients’ risk of their disease getting worse or their passing away from any cause by more than 60%
Click here if you are a healthcare professional.
Revlimid® is a registered trademark of Celgene Corporation.
Velcade® is a registered trademark of Millennium Pharmaceuticals, Inc.
E.C. | Patient
Living with multiple myeloma since 2010
My multiple myeloma journey began when I thought I had pulled a muscle playing racquetball. I initially thought it was nothing and consulted my doctor, who agreed that it was probably a pulled or bruised muscle and sent me home. After 8 months, the pain was still there, and I went back to my doctor for a checkup. Concerned that I hadn’t healed, my doctor ordered an ultrasound. There was a tumor on my rib. He told me that there was a strong possibility it was cancer and referred me to an oncologist, who confirmed I had multiple myeloma.
Initially, my doctor said that they wouldn’t start treatment but would monitor the disease to see if it progressed. I thought that was a good sign.
Soon afterwards, it was discovered that my multiple myeloma had worsened, so my doctor and I decided to start treatment immediately.
During my treatments, I never stopped playing racquetball. Eventually, I suffered an injury during a game that led to a Class 5 shoulder separation and a heart seizure for which my doctor recommended inserting a pacemaker. A few weeks later, I began suffering extreme chest pains and was immediately brought to the hospital, where they found clots in my lungs. I was told that my multiple myeloma treatment would have to be stopped. While that was discouraging, my family and I were even more shocked to learn that my wife, Lynn, had been diagnosed with recurrent metastatic breast cancer and needed chemotherapy.
Thereafter, my doctor suggested that I get a stem cell transplant—I was completely overwhelmed. I wanted to be there for my wife, but she insisted I get the treatment. With her permission and persistence, I underwent the procedure. Afterwards, Lynn helped me to recover. Sadly, soon after that, she passed away.
Not too long after, my cell counts worsened, and I was placed on a different combination therapy. During that time, I didn’t think there would be any treatment opportunities for someone at my stage of multiple myeloma. But a friend e-mailed me to let me know that a multiple myeloma specialist would be giving a talk. I went to the meeting and was captivated. Afterwards, I spoke to the specialist about my condition, and he asked that I come to his office the next day.
After our appointment, I was prescribed DARZALEX® and soon received my first treatment.
Over the past years, I have learned to cherish moments with loved ones and stay grateful. Additionally, I encourage everyone to discuss treatment options with their healthcare professionals.
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